12/28/2022 0 Comments Half life of gabapentinAs prepared, the transdermal route is an inappropriate choice for drug administration. Repeated oral dosing of gabapentin did not alter the drug's pharmacokinetics, making dose adjustments unnecessary with long-term treatment. Bioavailability after a single oral dose was 94.77% (82.46-122.83). The oral terminal half-life was 3.63 hours (2.96-4.77), and 3.72 hours (3.12-4.51) for single and repeated dosing. Compartmental analysis was used to generate gabapentin time-concentration models.Īfter IV administration CL (median (range)) and terminal half-life were 160.67 mL/kg*hr (119.63-199.11) and 3.78 hours (3.12-4.47), respectively. Plasma concentrations were determined using Ultra Performance Liquid Chromatography-Mass Spectrometry. Serial blood samples were collected up to 48 hours. Gabapentin was administered as an IV bolus (5 mg/kg), orally (10 mg/kg) as a single dose or twice daily for 2 weeks, or as a transdermal gel (10 mg/kg) in serial order. To evaluate the pharmacokinetics of clinically relevant dosing regimens of gabapentin in cats.Ĭats were enrolled in a serial order, non-randomized pharmacokinetic study. Despite this common and chronic usage, clinically relevant pharmacokinetic data is lacking. Gabapentin is the most commonly prescribed medication for the treatment of chronic musculoskeletal pain in cats.
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